Jenga building7/1/2023 ![]() The electric bill to heat a building of this size would be astronomical, if not for the geothermal wells that rely on the earth’s relatively constant temps to provide heat in the winter and to remove it in the summer. ![]() The Wu administration also wants Boston to be one of 10 communities in the state to be allowed to impose bans on fossil-fuel hookups for most new construction.Īn interior view of the main stairway to the lobby. Within a few years, Boston officials will start requiring that systems in large and midsized buildings gradually move toward net-zero emissions. ![]() “It’s not the optics, but the realization it can be done.” “It’s a tremendous moment,” said Joe Curtatone, president of the Northeast Clean Energy Council. The completion of the structure, built by Suffolk Construction and designed by KPMB Architects, represents an important milestone for state and city efforts to push building systems toward the point in which they do not result in an increase in carbon emissions. BU leaders say it’s also the biggest geothermal building they’re aware of to go up in a dense urban environment anywhere in the United States. Ryan/Globe StaffĪs it opens to professors and staff this month, and to students next month, the tower will be by far the largest net-zero carbon building in Boston, and probably all of New England. Boston University's new Center for Computing & Data Sciences will be the greenest tower in the city. ![]()
0 Comments
New simcity 4 deluxe edition7/1/2023 ![]() ![]() ![]() However, it was criticized for its difficulty and its demands on computer performance. It received widespread acclaim, won several awards, and was one of the top ten selling PC games of 2003. SimCity 4 was praised for being the first game in the main SimCity series to primarily use a 3D engine to render its graphics, following the implementation of 3D graphics in SimCity 64 for the Nintendo 64DD. External tools such as the Building Architect Tool (BAT) allow custom third-party buildings and content to be added to the gameplay. SimCity 4 introduces night and day cycles and other special effects for the first time in the SimCity series. For the success of a city, players must manage its finances, environment, and quality of life for its residents. Players can zone different areas of land as commercial, industrial, or residential development, as well as build and maintain public services, transport and utilities. ![]() The game allows players to create a region of land by terraforming, and then to design and build a settlement which can grow into a city. SimCity 4: Deluxe Edition contained the original game and Rush Hour combined as a single product. SimCity 4 has a single expansion pack called Rush Hour which adds features to the game. It is the fourth major installment in the SimCity series. The game was released in January 2003 for Microsoft Windows and in June 2003 for Mac OS X. SimCity 4 is a city-building simulation computer game developed by Maxis, a subsidiary of Electronic Arts. ![]() List of escort websites7/1/2023 ![]() ![]() With that in mind, we’ll try to even things out by including on our list. These contain multiple listings but only a few reviews. If you’ve had the chance to browse at least a few escort sites, then it’s obvious how many are fake. Lastly, Erotic Monkey has a good blog as well as a forum underpinned by a large and active member base. Even better, you can always take advantage of their excellent advanced search engine that factors in names, e-mail, state, services, fetishes, etc. Throw into a mix some pornstar escorts too.įurthermore, navigating the site is very simple. Besides reading reviews or checking out photos and contact info for TS and female escorts, you can also submit reviews. This place has around 30,100 US escort reviews, and all it takes to access them is a free registration. #10 EroticMonkey ( eroticmonkey.ch)ĮroticMonkey found itself on our list thanks to its huge database of first-hand customer accounts. Add to that good search features, profiles with photos, reviews, and you get one of the best escort sites. This place covers most of the western world (Europe and the US) and a few countries around the globe.Īll in all, you’re getting thousands of males, shemales, and female escorts. Whether you’re into dates, massages, or straight-up BDSM, you’ll have no trouble finding someone for you on EscortDirectory. For example, there are categories for location, ethnicity, hair color, affiliation, pornstar, college girls, matures, etc. Moreover, to help you narrow down search results, Eros also has a good sorting system. ![]() Among a slew of services, the girls and shemale escorts here offer BDSM and fetish sessions, girlfriend experience, and massages. Using the platform, you can hire high-class companions in the US, Canada, and England. Without a doubt, is among the most popular escort websites around. Moreover, these pages also offer many excellent user features, escort reviews, and extras that we’ll reveal below. Not to mention awesome pornstar escort services. These places list all kinds of services in dozens of countries across the globe featuring males, females, and shemales. So, here’s your top 10 of the best escort sites for 2023. ![]() However, we are here to make things even simpler. With so many sites offering all kinds of escort services, treating yourself to a good time has never been easier. ![]() Jibber jabber toy commercial7/1/2023 ![]() The pamphlet lists seven ways to react positively to a child rather than resorting to violence.” When Ertl was told about Shaken Baby Syndrome, the company responded, as reported by the US Advisory Board on Child Abuse and Neglect, by “plac an insert in Jibba Jabber packaging explaining that while Jibba Jabber is for fun, a lethal form of child abuse involves the shaking of babies. The distinguishing property of the Jibba Jabber was the distinct ‘choking’ or ‘strangling’ sound (resembling a groan tube) made by the wobbling head when shaken. Jibba Jabber) had a pink body with pink nose and the male version had a black body with yellow nose. The female version of the doll (called Ms. The dolls came with various hair colors including red, blue, pink and green. “Jibba Jabber was a doll made by the toy company Ertl in the mid-1990s. Somehow today, my dazed mental repetition of “Get up! Get up! Get up!” invoked the spirit of Jibba Jabber, and I heard those words again.Īddendum: While I was looking up photos for this post, I came across the following at Wikipedia: My kids loved it and shook it all the time, so its head wobbled back and forth and it talked and talked and talked.īack in those days, in the depths of sleep deprivation with three small children, whenever Jibba Jabber talked, I heard it say two things clearly: “Help me! Help me! Help me!” and “Wake up! Wake up! Wake up!” Always in squeaky groups of three. (Odd concept, really!) When you vigorously shook it, it made “jibba jabber” sort of squeaky talking sounds that you were encouraged to interpret into some demented sort of conversation. You were supposed to grab it at the neck and shake it. ![]() It was a weird looking long-necked creature. (To this day my husband looks uneasy when I mention Ernie.)īut this morning, I heard echoes of one of my children’s toys called a Jibba Jabber. We reassured ourselves that it was an odd battery quirk, but I’m still not so sure about that one. My husband and I would wake with a start in the depths of the night to odd noises coming from the living room. Every night! (At least I’m pretty sure it was my siblings…) My son had a Sleep and Snore Ernie that used to come to life at night. As a child, I had a wonderful reversible Red Riding Hood doll that I adored…until my siblings changed it to the wolf head and rested it on my pillow. You know how there are those odd, somehow disturbing toys that can haunt you? Some from your own childhood? Some from your children’s? I can think of several in each category. ![]() The wolf’s head is hidden under Granny’s cap on this Topsy Turvy doll. ![]() Annoying loud to get scrutiny from7/1/2023 ![]() ![]() ![]() MM: Only after we talk about the bulimia. In “Spencer,” as in the Apple TV + series “Physical,” self-induced vomiting gets a lot of screen time, and in both cases, I have been impressed with how it is depicted: Not as some kind of bizarre dieting technique but as a fear-born compulsion and an attempt to exert control. There has been some criticism of Larraín’s decision to depict Diana vomiting as often and as graphically as the film does, but for me, it grounded all the gothic horror aspects of the film in reality. #Annoying loud tv to get scrutiny series.#Annoying loud tv to get scrutiny install."But we're going on the roller coasters again." "I'll think about it," he said even though he'd already made up his mind. Even though you said it was OK, he figured you'd be disappointed if you weren't able to go in just because of him. No, he didn't particularly like haunted houses, scary movies, or any of that shit it wasn't that any of it actually scared him, though. Katsuki eyed you with scrutiny before taking a sip of water. " You shrugged you didn't want to convince him to do something he really didn't want to do. "Really? I somehow pegged you as someone who would like that type of thing. Now, that was a surprise to you, and it must've shown on your face from the way his eyebrow inched upwards. I don't like scary movies or stuff like that." He looked up from his eggs and practically sneered. "Ooh, Katsuki! They put up spooky stuff in the park for the fall weather! Do you like haunted houses?" Party pooper.Īs you ate your food - with chopsticks just to practice more and prove that you could - you browsed the website of the theme park to see if there were any special events happening or new attractions. No dessert for breakfast must've been one of his unspoken rules. Mochi isn't breakfast," he argued before turning off the stove. "Too bad, you can have some tonight when we get back. "I forgot to try some last night," you whined while pulling down some plates. but you'd play it by ear before you said anything too raw that you couldn't take back.Īfter the two of you showered - no time for funny business this morning - Katsuki made a quick and easy breakfast while slapping your hand away from the package of mochi you bought. Depending on how the day went, the potential for a heartfelt confession seemed strong. Weeks later he was still sweeping you off your feet. Apparently, you were standing there for a second too long because he smirked, stretched once more with the obvious intention of flexing his very defined shoulders and arms, and waltzed over to you for a lip-to-lip good morning kiss that definitely woke you up. When you came back, you found Katsuki already up and stretching, rippling muscles seizing your attention like a suncatcher arresting sparkling sunshine. "Ooh, theme park date! Guess someone's excited." It was only then when you looked at your pillow-ruffled hair in the mirror under the too-bright bathroom lights that you realized it was Saturday. ![]() "Chotto matte," you said with a finger in his face before walking out of the room to use the bathroom and brush your teeth. It was enough of a distraction to wiggle out of his grip and land on your feet, tired wobbliness aside. Too half asleep to reciprocate his early morning enthusiasm, you reached up to place your palm on his cheek before turning your head to kiss the side of his face. "Ohayo, (y/n)," he whispered in your ear, sending a slight shiver down your spine. " Katsuki."Ī soft chuckle like morning birdsong. A strong arm snaked around your middle and warm breath tickled your ear a few seconds after you closed your eyes again. "Alright, ALRIGHT, fucking.too early." You groaned and shoved Katsuki away weakly in a pitiful attempt to get him to stop pinching your sides before rolling over to shut off your phone. Namely a plan that consisted of annoying you awake so that you shut off your damn phone. However, this very alive wall had other plans in mind. You were far too sleepy to remember what day it was or why you'd set the alarm in the first place, instead deciding to cushion yourself against the wall of warmth under your sheets. The alarm, oh the dreaded alarm blared in your ears like a siren song entrancing you to wake up. ![]() Microsoft onenote logo7/1/2023 ![]() ![]() ![]() Microsoft OneNote users can log in notes, drawings, audio commentaries, and screen clippings to their notes. The logo images appearing on Logo.wine website are not associated with or sponsored by the copyright and/or trademark holder. What is Microsoft OneNote Microsoft OneNote is a digital note-taking application for gathering information backed up to Microsoft’s Office 365 cloud. Similar to apps like Evernote and Dropbox Paper, it lets you store text and images in free-form. In the ribbon, click 'Ink to Text.' Select handwritten script and then convert. ![]() Drag the lasso around the text you want to covert. Download 28146 free Microsoft onenote logo Icons in All design styles. Logo.wine does not warrant that any of the materials on its website are accurate, complete or current. Microsoft OneNote is an app that is designed for research, note-taking, and information storage. Click the 'Draw' tab in the ribbon and click 'Lasso Select.' 2. For any usage of Microsoft OneNote logo and brand elements, please contact Microsoft OneNote directly to request a licensing agreement.īy downloading the Microsoft OneNote logo from Logo.wine you hereby acknowledge that you agree to these Terms of Use and that the artwork you download could include technical, typographical, or photographic errors. To dictate text in OneNote for Windows 10 and the OneNote web app, open one of your notebooks and click the spot on the page that you want your text to appear. The content of this site is provided on an “as-is” and “as available” basis, and it is intended for non-commercial, informational purposes only, to educate and inform its website visitors about the Microsoft OneNote logo.Ī third party person or company should never use the Microsoft OneNote logo without the written permission of the copyright and/or trademark holder. Mac Logo png is about is about Microsoft OneNote, Microsoft, MICROSOFT OFFICE, Application Software, Microsoft Office For Mac 2011. ![]() Captor therapeutics7/1/2023 ![]() The results reflect performance of a strategy not historically offered to investors and does not represent returns that any investor actually attained. Backtested performance is not an indicator of future actual results. +41 (0)76 735 01 A prodrug is a biologically inactive compound which can be metabolized in the body to produce a drug which is pharmacological active.Cash, Cash Equivalents and Short-Term Investmentsĭisclaimer: The TipRanks Smart Score performance is based on backtested results. LinkedIn: and investor contacts: Polish Media and Investor Relations: Captor is currently developing treatments for undertreated serious conditions, including cancer and autoimmune diseases.įor more information on Captor Therapeutics, visit : TPD is a revolutionary approach to developing new drugs that can target new molecular targets considered undruggable" using classical drug modalities and provide additional treatment options for diseases where existing drugs do not provide optimal treatment. Potent degradation and first-in-class selectivity profile of the molecular target PKCӨ in immune cells in vitroĬaptor Therapeutics is a drug discovery and development company applying targeted protein degradation (TPD) technology to discover and develop breakthrough drugs for diseases with significant unmet medical need.In preclinical studies, CT-05 has demonstrated attractive features that differentiate CT-05 from inhibitors that failed in clinical trials due to side effects: the potential of the PKCӨ protein pathway is underpinned by BMS's latest in-licensing of Exscientia's PKCӨ inhibitor EXC4318.The IL-17 pathway is a clinically validated pathway in autoimmune diseases such as psoriasis with established modulators 2 the PKCӨ protein acts via the CD3/CD28 – IL-2/IL-17 pathway.Importantly, the approach behind CT-05 is partially de-risked thanks to: PKCӨ is a high-value target with opportunities in certain autoimmune diseases, such as allergy, psoriasis, and inflammatory bowel disease, as well as certain malignancies, such as breast and gastrointestinal cancer. It is therefore expected that degrading the PKCӨ protein would lead to an increased T cell suppressive function. Indeed, PKCӨ plays an important role in the modulation of T cells by limiting the suppressive function of T cells. Compounds with the ability to cross the blood-brain-barrier have been identified and provide opportunity for further development in the area of neurodegenerationĬT-05 targeting (new disclosure) PKCӨ (PKC theta)ĬT-05 targets the PKCӨ protein, a protein highly relevant in both autoimmune diseases and cancer.Optimised compounds with good pharmacokinetics in animals have been developed.Degradation of NEK7 is correlated with the desired in-vitro biological effects on the inflammatory response.Effective NEK7 degradation at low concentrations in vitro (high potency) and ex vivo.Pre-clinical studies have revealed the following benefits of CT-02: It is therefore expected that selective degradation of NEK7 would also remove the NEK7 scaffolding function leading to potent inflammatory inhibition. Importantly, it is established that NEK7 pro-inflammatory activity is largely driven by its scaffolding function, and because of that, classical inhibition of NEK7's kinase function doesn't provide therapeutic benefit. Such NEK7 degradation allows the modulation of the inflammasome, a complex that plays a critical role in the regulation of the inflammatory response.Ĭaptor believes that selective NEK7 degraders have the potential to overcome the limitations shown in the past of NLRP3 inhibitor drugs related to increased susceptibility to infection. In addition to the potential benefits of NEK7 degradation combined with the degradation of GSPT1 and SALL4 in cancer, as mentioned above for the CT- 01 Project, the selective degradation of NEK7 alone in the CT-02 Project has many potential benefits as a treatment of several autoimmune diseases. Moreover, CPT-6281 is particularly well suited for liver, lung, and neuroendocrine tumors since it is a prodrug 1 activated by an enzyme present in high concentration in the liver, the lungs, and some gastrointestinal tumors. GSPT1 is a protein involved in the termination of translation, SALL4 is a transcription factor often over-expressed in HCC patients and correlating with poor prognosis, and NEK7 is a protein in which degradation leads to a reduction in IL-1b production, a well-known pro-carcinogenic factor. ![]() The first indication will be in Hepatocellular Carcinoma (HCC).ĬPT-6281 is a first-in-class degrader of GSPT1, SALL4, and NEK7. CT-01 / CPT-6281 targeting GSPT1, SALL4 and (new disclosure) NEK7ĬT-01 / CPT-6281 is currently undergoing IND/CTA-enabling studies with the first clinical trial expected to start at the end of 2023. ![]() ![]() This is because HECM reverse mortgages are only available to Americans that are at least 62 years of age. In terms of refinancing reverse mortgages, the motivation for doing so can come from a number of places that tend to be a bit more specialized. Refinancing conventional, forward mortgages is a very common practice that some borrowers utilize in order to try and create more favorable terms as they work to pay off their home loan. Refinancing can come with several possible benefits, including increasing the amount of money that you’re able to borrow from the loan, along with taking into account other factors that may have shifted into your favor since the original loan was first created, particularly in terms of interest rates and/or principal limit factors ( PLFs). The short answer to this is yes, it is possible to refinance a HECM reverse mortgage. Bank of England Mortgage is not affiliated with any government agency.For some existing reverse mortgage borrowers – particularly borrowers who have a Home Equity Conversion Mortgage ( HECM) sponsored by the Federal Housing Administration (FHA) – a number of factors may lead them to ask if it is both possible and/or beneficial to potentially refinance their existing loan into an offering with more advantageous terms. This contact information is for accommodation requests only.īank of England Mortgage is a division of Bank of England. If you are an individual with disabilities who needs accommodation, or you are having difficulty using our website to apply for a loan, please contact us at (866) 878-BANK. You should verify all information before relying on it and decisions based on information contained in our site are your sole responsibility. The information published on this site is provided as a convenience to visitors and is for informational purposes only. Bank of England Mortgage may change the products, services, and any other information described on this site at any time. From time to time changes may be made to the content of this site without notice.
|